Alosetron HCl
Alosetron is indicated only for women with severe diarrhea-predominant irritable bowel syndrome (IBS-D) It was patented in 1987 and approved for medical use in 2002. It is currently marketed by Prometheus Laboratories Inc. (San Diego). Alosetron was withdrawn from the market in 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, but was reintroduced in 2002 with availability and use restricted.
Systematic Name
5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one;hydrochloride
Brand Name(S)
Lotronex
Therapeutic Category
Irritable bowel syndrome
Suitable Formulations
Solid
Approvals
US DMF
EU-WC